Did the World Just Gain Hundreds of Millions of Alzheimer’s Patients?

A new definition of Alzheimer’s includes people without symptoms. Experts are fiercely divided over whether that makes sense—and whether the new drugs really help.

以血液檢測澱粉樣蛋白為核心的生物標志物定義，把大量沒有症狀的人划入阿爾茨海默病，使全球可能“患病”的人數達到數億。文章追溯這一定義的歷史與藥企利益糾葛，並指出抗澱粉樣蛋白藥物對認知衰退的延緩幅度有限，多數標志物陽性者終身不會發展為痴呆。