Sleep and depression may be more intertwined than we thought

Depression tied to the body’s sleep cycle could be less responsive to antidepressants and cause more severe symptoms

一种较少为人知的抑郁亚型"昼夜节律性抑郁"可能由睡眠—觉醒周期紊乱引起，其症状可能比其他类型更严重。一项针对11380名抑郁症患者的研究显示，近四分之一符合该亚型标准，且抗抑郁药对"夜猫子"效果更差。